High Dose Vitamin C - Combination Therapies for Cancer Patients

CancerHelpful Information
Written By

High Dose Vitamin C - Combination Therapies for Cancer Patients

The Synergy of Combination Therapies - Lets Review This is because most of the studies on heavily pretreated patients undergoing chemotherapy did not yield impressive results on improvement of overall survival (on most cancers) by VIT C alone. This does not mean IV vit c is to be forgotten or that it is not useful. When used in combination with other techniques, off-label drugs, immunotherapies, or low-dose metronomic chemotherapy, it may be highly beneficial.For example:Vitamin C + PARPInhibitorsA study combined Vitamin C with a PARP inhibitor, olaparib, in 8 patients with stage 4 progressive disease, most had completed all standard of care chemotherapies.The results were striking: out of 8 very late stage patients, 3 had complete responses, and 5 had partial responses. Including one pancreatic cancer patient who was still alive 18 months after starting the treatment.https://journals.sagepub.com/doi/full/10.1177/1534735420969812️ Vitamin C + Checkpoint Inhibitors + HyperthermiaAnother study combined Vitamin C with low-dose checkpoint inhibitors and hyperthermia. The objective response rate was 31.3%, and survival probabilities at 12 months were 66.5%. Notably, the study suggests that the irAEs profile of the combined treatment is safer than that of the established protocols without compromising efficacy.One complete response to this treatment was posted in the group:https://www.facebook.com/groups/patientledoncologytrials/permalink/685980288799818https://link.springer.com/article/10.1007/s00262-020-02751-0Immunogenic Cell Death (Hyperthermia) + VIT C: A New FrontierA remarkable study shows how we can potentially increase life expectancy by a significant amount, anywhere from 100% to 500% more than the usual treatment. In this study, 97 patients were given intravenous vitamin C and hyperthermia (heat therapy) three times a week for a total of 25 treatments over three monthsTo understand the impact, the average time people lived went from 5 months to 9.4 months with just three months of treatment (the study ended after that).Progression-free survival was: 3 months vs 1.85 months.The group that received intravenous vitamin C had a higher rate of controlling the disease (for at least three months).If the treatment had continued indefinitely (which was not part of the study), we can imagine that the results would have been even more significant!https://www.sciencedirect.com/science/article/pii/S2090123220300539The proposed benefit of IV vit c + immunogenic cell death inducers has been well documented in laboratory studies . In this case an Oncolytic vilus has been used to sensitise to vit c treatmenthttps://pubmed.ncbi.nlm.nih.gov/34547462/Other well known ICD are: low dose radiotherapy, Dinaciclib, Disulfiram+copper or IvelmectinIV VIT C + chemotherapy OR targeted therapyPancreatic Cancer: Several phase I/II studies showed trends towards slight increased (but very slightly hence Mark’s post) disease control and objective response rates, although they were not designed to definitively prove efficacy.Ovarian Cancer: In a randomized trial, the median time for disease progression was 8.75 months longer when ascorbate was added to standard chemotherapy, compared to chemotherapy alone. (this is the only clinical study showing great advantages with chemotherapy)https://pubmed.ncbi.nlm.nih.gov/24500406/Targeted Therapy: Three non-randomized studies showed some efficacy when IVC was combined with targeted agents. In one study, 8 out of 9 patients with metastatic stage IV pancreatic cancer showed tumor shrinkage after only 8 weeks of treatment (in conjunction with erlotinib and iv VIT C)https://jeccr.biomedcentral.com/articles/10.1186/s13046-021-02134-yOngoing Trials and Phase I/II StudiesSeveral ongoing trials and studies are exploring the added benefit of high-dose IV Vitamin C to standard chemotherapy in pancreatic and prostate cancer.For those interested by all the combination therapies, you can take a look at the combinations already studied herehttps://jeccr.biomedcentral.com/articles/10.1186/s13046-021-02134-yDisclaimer: This website does not provide medical advice. The information including text, graphics, and images, are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment.

Read More...

Previous

Anemia and Cancer
Next

Resveratrol & Breast Cancer