Feverfew and Cancer Cells

CancerHelpful Information
Written By

Feverfew and Cancer Cells

Parthenolide, a sesquiterpene lactone and the principle bioactive ingredient of the herb feverfew, has been shown on multiple occasions to attack cancer stem cells largely through the nuclear factor kappa-B pathway.What is Feverfew?Feverfew (Tanacetum parthenium) is a flowering perennial plant belonging to the Asteraceae (daisy) family. It is a truly powerful herb because of several bioactive ingredients called sesquiterpene lactones , including one in particular - Parthenolide, found in the largest concentration in the flowers and the fruit. Native to the Balkan Peninsula, feverfew is now widely cultivated across the globe.It has multiple pharmacologic properties, for example: anti-inflammatory, anticancer, cardiotonic, suppression of muscle spasms, stimulating menstrual flow and as an enema for wormsFeverfew and cancer stem cells - the researchParthenolide doesn’t just attack cancer cells; it attacks cancer stem cells. And when no cancer drug currently seems capable of this, the finding is particularly important. So much so, that the FDA promised to 'fast track' the development and use of feverfew in 2005. We are still waiting.

  • Pancreatic cancer - Parthenolide and a non-steroidal anti-inflammatory, sulindac, synergistically brought about growth suppression and inhibited the nuclear factor-kappa B pathway in pancreatic carcinoma cells. Research showed that parthenolide could inhibit pancreatic cancer cells’ proliferation and cause apoptosis.
  • Breast cancer - Researchers from Indiana Medical School were looking at what might tackle NF- kappa B, which is known to promote pancreatic cancer cell migration; their research had previous shown that NF-kappa B caused cancer cell migration in breast cancer too.Dr Nakshratri of Indiana showed that a daily intake of Parthenolide could suppress metastases ‘in vivo’ in mice with breast cancer and could increase the response to Paclitaxel (taxol).By 2013 other Sesquiterpene lactones, such as costunolide, were being studied alongside parthenolide. Both were shown to selectively decrease detyrosinated tubulin in cancer cells independent of their inhibition of NF-κB.The two compounds showed reduction in the frequency of microtentacles and inhibition of reattachment in breast cancer. Better still, parthenolide and costunolide can decrease detyrosinated microtubules without significantly disrupting the overall microtubule network or cell viability. Thus they selectively attack cancer cells, whereas researchers showed Paclitaxel and colchicine were indiscriminate in their disruption of the microtubule network.
  • Leukaemia - A team of researchers including Monica Guzman, PhD, of the University of Rochester Medical School, showed that Parthenolide was a potent anti-leukaemia aid and could kill cancer stem cells, without damaging healthy cells. It was also compared in the studies to the drug Cytarabine, commonly used at that time for leukaemia. The Parthenolide gave significantly better results.Cancer stem cells are not killed by any chemotherapy drugs, and live to fight another day, helping the tumour to grow again. For this reason they are sometimes called ‘Initiating Cells’A study in animals infected with child leukemia (ALL) took place. The Parthenolide killed the Leukaemia-Initiating cells.
  • Prostate cancer – Researchers at the National Cancer Institute were showing that Parthenolide could attack cancer stem cells in prostate cancer. (Prostate cancer, is second to Pancreatic cancer in terms of numbers of different cancer stem cells found in tumours.)
  • Lung cancer - Parthenolide can inhibit the tumour-promoting effects of nicotine in lung cancer. It could inhibit VEGF expression (a common factor in NSCLC) and induce apoptosis. Both parthenolide and costunolide and found in magnolia. Honokiol (the best supplements also contain magnol) comes from the magnolia bush and is also known to have these anti-cancer and anti-proliferative effects in many cancers including lung cancer.

Direct Link :https://madefromroots.com/product/feverfew-glycerite/Disclaimer: This website does not provide medical advice. The information including text, graphics, and images, are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment.

Read More...

Previous

Bloat Busting Pineapple & Ginger Wellness Shots
Next

Stuffed Kumara